Findings expand on previous discoveries in mice
A recent study showed that a full week of auditory interventions improved spatial and recognition memory and reduced amyloid in auditory cortex (AC) and hippocampus of mice.
A previous report in Cell showed that inducing gamma oscillations with a non-invasive light flicker impacted pathology in the visual cortex of Alzheimer’s disease mouse models. This is a concept known as gamma entrainment using sensory stimulus, or GENUS. In this example, researchers designed auditory tone stimulation that drove gamma frequency neural activity in AC and hippocampal CA1.
After seven days, the reduction in amyloid and hippocampus were apparent, as were changes in activation responses in microglia, astrocytes, and vasculature.
Lastly, combined auditory and visual GENUS (when used together) produced microglial-clustering responses and decreased amyloid in the medial prefrontal cortex.
The researchers, led by Anthony J. Martorell of the Massachusetts Institute for Technology (MIT), concluded that GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function.